Mass Spectrometry based Metabolomics Profiling

Waters ACQUITY UPLC - Dramatic Improvements in Speed, Sensitivity and Resolution Whether you work in methods development or quality assurance, in drug discovery and development or testing for safety in food supplies, you seek a productivity edge. With the ACQUITY UPLC® System, now you can get more information in a single, short run than you've ever seen with HPLC. Waters ACQUITY UPLC System UltraPerformance LC® (UPLC®) technology starts with unique 1.7 μm small-particle chemistries. Chromatographers no longer need to choose between speed and resolution–with UPLC you get both. Instrument Designed for Chemistry; Chemistry Designed for the Instrument The ACQUITY UPLC System has been holistically designed to match the performance needs of our innovative column chemistries with robust hardware, easy-to-use software and specialized support services. Small, pressure-tolerant particles High-pressure fluidic modules Minimized system volume Negligible carryover Reduced cycle times Fast response detectors Integrated system software and diagnostics With UPLC you have the ability to work more efficiently with higher speed, sensitivity and resolution at a much wider range of linear velocities, flow rates and backpressures to obtain superior results. The Waters ACQUITY UPLC System's high-pressure fluidics optimizes flow rates to make the most of small particle technology. The ACQUITY UPLC System's sample-handling design is designed to ensure exceptionally low carryover and reduced cycle time. And when interfaced with the Sample Organizer, it increases unattended sample capacity by ten times. High-speed detectors, both optical and mass, contribute to increased sensitivity and help manage the heightened speed and resolution requirements of UPLC. ACQUITY UPLC Systems are easily controlled, diagnosed, and monitored via a graphical system console interface. The console offers: Quick and easy access to critical instrument parameters Simple system start-up, elegant system status monitoring and predictive performance indicators to ensure maximum productivity Data management capabilities that are supported by both MassLynx™ and Empower™ software The ACQUITY UPLC System is also supported by Intelligent Device Management technology with our Connections® INSIGHT™ service, providing instrument diagnostics.

Market Leading LC-TOF-MS with Unrivalled Sensitivity, Exact Mass and Dynamic Range for Qualitative Applications The Waters LCT Premier™ XE is the market-leading orthogonal acceleration time-of-flight (oa-TOF) benchtop mass spectrometer for LC applications. Based on proven and reliable technology, the LCT Premier XE provides unrivalled all round performance for those challenging LC/MS applications. The LCT Premier XE's high sensitivity Z-Spray ion source, ion transfer optics and TOF analyzer provides the most sensitive benchtop oa-TOF instrument in its class, giving capability of detecting very low level components with full spectral information. Enhanced resolution (up to 15,000 FWHM over 30,000 m/z) spectral data provides the capability of high accuracy exact mass measurements providing improved data specificity through elemental composition calculations resulting in an increased confidence in your data. For challenging and complex samples, the rapid spectral acquisition rate and wide dynamic range provide optimized detection capabilities making it the ideal MS instrument for qualitative applications. The Waters LCT Premier XE provides a powerful platform for MS analyses, upon which total system solutions may be designed to maximize data quality for your application. Its small footprint sits easily on your laboratory benchtop and is optimized for simplified fluidic connections to your LC system. When combined with ACQUITY UPLC, the LCT Premier XE provides optimized full spectral MS detection for UPLC separations, providing unsurpassed speed sensitivity and resolution for high throughput applications.

Acquire, Analyze, Manage, and Share Mass Spectrometry Information MassLynx™ Software increases the speed at which you can convert your sample data into valuable knowledge. It provides you with the fundamental platform to acquire, analyze, manage, and share your mass spectrometry information. MassLynx intelligently controls any Waters mass spectrometry system, from sample and solvent management components to mass spectrometer and auxiliary detectors. MassLynx Software may acquire nominal mass, exact mass, MS/MS and exact mass MS/MS data. MassLynx’s Sample List is the core of the system. It maintains and consolidates the data on all of your samples. You also initiate any activities related to your sample from the Sample List. This "sample centric" approach simplifies the interaction with your LC/MS or GC/MS system, acquired data and processed results. Process Application-specific Data MassLynx Software features general purpose and specialized Application Managers that provide information for your specific MS analyses and data. Two come standard with MassLynx: QuanLynx™ for automated quantification included as standard with MassLynx OpenLynx™ for qualitative screening and identification Optional Application Managers can perform: Targeted quantitative analysis Mass-directed purification Metabolite identification Deconvolution of complex chromatograms Metabonomics & metabolomics Protein identification and protein characterization