Monoclonal gammopathies: From warning signs to investigation

7 Sept 2026

This video explains plasma cell disorders, including MGUS (monoclonal gammopathy of undetermined significance), smoldering multiple myeloma, and multiple myeloma. It highlights the role of plasma cells in antibody production and the implications of a single clone overproducing monoclonal antibodies. Early detection through blood tests like SPEP (serum protein electrophoresis) and serum free light chains is emphasized, along with the importance of primary care provider collaboration with hematologists for accurate diagnosis and management.

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Binding Site

Binding Site, part of Thermo Fisher Scientific, is committed to improving patient lives worldwide through education, collaboration and innovation

Binding Site provide diagnostic solutions that help doctors, clinicians and laboratory researchers across the globe diagnose and monitor blood cancers and immune system disorders.

Founded by researchers at the University of Birmingham, Binding Site has continued to build on its strong scientific foundations, supporting research and development within our field and responding to the changing needs of patients, researchers and clinicians for over 30 years.

We are committed to working in collaboration with our partners and customers to lead the way in specialised medical diagnostics, ensuring we continue to make a difference together.

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Freelite™ Assays

Binding Site

Detect and monitor Multiple Myeloma (MM) with Freelite® assays. The time-tested and proven solution for kappa and lambda serum free light chain (sFLC) analysis

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Clinical ChemistryBiochemistry (or clinical chemistry) involves the analysis of bodily fluids using chemical tests. Techniques used include HPLC, chromatography, spectroscopy, mass spectrometry, immunochemical, electrophoresis, turbidometric / spectrophotometric assay, MRI and ISE analysis. Tests are often carried out on plasma or serum but urine (urinalysis) and fecal specimens are also processed.Multiple Myeloma