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7 Top Mass Spectrometry Innovations from ASMS 2019

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SelectScience editors reflect on the best technologies and advancements highlighted at this year’s American Society for Mass Spectrometry conference

10 Jun 2019
Kerry Parker
CEO

Editorial article

Thousands of scientists attended the 67th annual American Society for Mass Spectrometry (ASMS) conference last week in Atlanta, Georgia, USA. SelectScience editors attended the show to report on the latest and greatest in mass spectrometry and the allied topics — here we cover the most exciting innovations in this field, as presented by seven exhibitors.

InfinityLab LC/MSD iQ System by Agilent

Agilent introduced its intelligent LC/MS system, desgined to be an intuitive quadrupole, which incorporates 'designed-in' smart features, software, and hardware specifically for chemists and chromatographers. Monty Benefiel, Vice President and general manager of Agilent's Mass Spectrometry Division, declares that "the InfinityLab LC/MSD iQ System is the simplest and quickest path to robust, reliable, and routine mass-based detection." Find out more about what this new system can do for your lab here.

SELECT SERIES Cyclic IMS and SYNAPT XS by Waters

Waters unveiled two new high-resolution mass spectrometry systems, the novel SELECT SERIES cyclic IMS and new SYNAPT XS, designed to address the most challenging analytical needs. SELECT SERIES Cyclic IMS integrates cyclic ion mobility (cIM) technology into a high-performance research-grade time-of-flight mass spectrometer, aiming to provide limitless experimental potential. Mike Wilson, Director, Product Marketing Mass Spectrometry Systems, also reiterated the value of Water's BioAccord LC-MS System for biopharmaceuticals: "The BioAccord System continues to excite our biopharmaceutical customers as they contend with the increasing complexity of their molecules and business models." Find out more here.

New intelligence-driven portfolio from Thermo Fisher Scientific

The Thermo Fisher Scientific Orbitrap Exploris™ 480 mass spectrometer was unveiled as a system designed to combine proven technology with advanced capabilities and intelligence-driven data acquisition techniques. Enabling researchers to deploy MS for more rigorous, high-throughput protein identification, quantitation and structural characterization. Thermo Fisher Scientific also announced its HR Multi-Attribute Method (MAM), designed to meet the demand for a single, high-resolution mass spectrometry-based workflow to directly assess the quality of increasingly complex biotherapeutics. Learn more about the latest additions to Thermo Fisher Scientific's portfolio here.

timsTOF fleX™ with ESI and MALDI for SpatialOMx™ by Bruker

Bruker's new timsTOF fleX™ with ESI and MALDI for SpatialOMx™ promises to be an invaluable research tool for spatially-resolved 4D proteomics and phenomics, as well as for advancing single-cell biology, pharmaco-proteomics, and translational 4D cross-omics workflows on large cell numbers or patient cohorts. Find out more about this release here.

TripleTOF® 6600+ LC-MS/MS System by SCIEX

SCIEX introduced the new TripleTOF® 6600+ LC-MS/MS system, with scanning SWATH® acquisition and OneOmics™ in SCIEX Cloud, is built for large-scale precise quantification in biomarker discovery and clinical research. The instrument incorporates simplified low-flow source technology to deliver accessible, sensitive and robust quantification; while multiple software-enabled improvements aimed to increase robustness and maximize system uptime. Acoustic Injection MS was also unveiled for the first time after several years of collaboration within the pharmaceutical industry. The new technique promises native mass spectrometry analysis with no sample prep for high throughput screening applications, with a commercially available product to follow. Find out more about the new tripleTOF here.

Amyloid MS Service and MALDImini-1 from Shimadzu

Shimadzu introduced its recently developed Amyloid Mass Spectrometry (MS) Service. This new test service for early screening of amyloid-positive subjects uses a combination of immunoprecipitation and MALDI-TOF mass spectroscopy (IP-MS) for early and accurate detection of amyloid deposition in the brain . Unlike conventional methods, Shimadzu’s new test is minimally invasive, cost-effective and suitable for large-scale deployment. Shimadzu also unveiled the MALDImini-1 Digital Ion Trap Mass Spectrometer, the first commercially available compact MALDI digital ion trap mass spectrometer. Read more here.

PerkinElmer presents new turn-key approach

PerkinElmer displayed a customer-first focus at ASMS. Aiming to provide a ‘painless’ service and trusted expertise to customers in the food safety and associated regulatory markets, from tools and templates such as Standard Operating Procedures, to software solutions designed to manage the complete flow and integrity of information.


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LC-MSLC-MS (liquid chromatography-mass spectrometry) systems and equipment are used for separation and quantitative analysis of complex mixtures, combining liquid chromatography and mass spectrometry. Quantify proteins, contaminants, pesticides or screen for drug metabolites with a high level of sensitivity. LC-MS systems and equipment include reverse phase, normal phase and specialized columns integrated with various MS detectors such as time-of-flight (TOF), quadrupole, orbitrap or ion trap mass analyzers. LC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzer give greater sensitivity and resolving power to your analysis. Find the best LC-MS equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. NMR and EPR SpectroscopyNuclear magnetic resonance (NMR) spectroscopy is used to resolve the local chemical environment of atomic nuclei with spin, revealing information on molecular structure, dynamic processes and chemical reactions of organic molecules, from proteins to synthetics. Electron paramagnetic resonance (EPR) also known as electron spin resonance (ESR) spectroscopy is used to detect and quantify paramagnetic species in a sample, including free radicals as transition metal ions. By immersing the sample in a strong magnetic field, both NMR and EPR spectrometers probe the sample with either radio waves or microwaves respectively. A range of benchtop, solid-state and time domain NMR spectrometers & EPR spectrometers are available, as well as NMR tubes, NMR solvents, software, coils, and magnets. Find the best NMR & EPR equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.GC-MS GC-MS (gas chromatography-mass spectrometry) instruments and equipment are used to separate, quantify and identify mixtures of small and volatile compounds, such as polycyclic aromatics, fatty acids and alcohols. Often used in drug detection, forensic investigation and environmental analysis for pesticides and contaminants, GC-MS is a powerful addition to your lab’s analytical capabilities. GC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzers can give greater sensitivity and resolution to your analysis. Find the best GC-MS instruments and equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.ASMSThe American Society for Mass Spectrometry (ASMS) is an organization dedicated to advancing the science and application of mass spectrometry. ASMS supports professionals through events, publications, and research initiatives, promoting innovation in areas like proteomics, metabolomics, and environmental analysis.

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