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A simple and straightfor­ward procedure for measuring functional kinase activity.The Eu(K) labeled antibody and XL665 conjugate are added simul­taneously after the enzymatic step. Results are available after a 2-hour incubation at room temperature. The two reagents are stable in solution, even in an excess of EDTA (0.5M), while the assay remains stable for >24 hours. An extended list of Eu3+-Cryptate labeled phos­pho-specific…

CRISPR/CAS9 Gene Editing of Human Induced Pluripotent Stem Cells (iPSCs)  

Streamline gene activation experiments with stably expressing dCas9-VPR cell lines

CompoZr ® ZFN (zinc finger nuclease) technology was used to insert the sequence for fluorescent proteins adjacent to endogenous genes to create reporter cell lines for compound screening

This pooled library targets the human kinome, a collection of approximately 700 genes commonly associated with development and disease, with an average of nearly 9 unique knockout CRISPR clones per kinase gene. The lentiviral format allows for stable integration, selection, and enrichment of transduced cells

Components of the Upstate (Millipore) Casein Kinase 2 Assay Kit:• Casein Kinase 2 Substrate Peptide (Cat.# 12-330) • Assay Dilution Buffer I (ADBI) (Cat.# 20-108) • PKA Inhibitor Cocktail (Cat.# 20-114) • Magnesium/ATP Cocktail (Cat.# 20-113) • P81 Phosphocellulose Squares (Cat.# 20-134) For use to measure the phosphotransferase activity of Casein Kinase 2 (CK-2) in immunoprecipitates and column fractions based on phosphorylat…

New agreement brings leaders in biomedical knowledge solutions and knowledge graph technologies together to aid the biopharmaceutical industry in analytics-driven drug discovery

Battery cover with wings for Corning Stripettor Ultra Pipet Controller

The CardioExcyte 96 is a 96 well plate-based hybrid device supporting highly resolved impedance-based measurements and electric field potential recordings. It analyses the contractility and electrophysiology of cellular cardiac networks, as well as morphological changes, e.g. cytotoxic responses, of non-contractile cells such as hepatocytes, cancer cells, cell lines or stem cells.

F(ab')2 fragments of antibodies are generated by pepsin digestion of whole IgG antibodies to remove most of the Fc region while leaving intact some of the hinge region. Used for specific applications, such as to avoid binding of antibodies to live cells with Fc receptors or to Protein A or Protein G. 

Fab fragment antibodies are generated by papain digestion of whole IgG antibodies to remove the entire Fc portion, including the hinge region. Block endogenous immunoglobulins on cells, tissues , or other surfaces. Block exposed immunoglobulins in multiple labeling experiments using primary antibodies from the same species. Fab-label primary antibodies in solution without compromising activity.

When purifying molecules, maximizing efficiency is critical to daily work.  The Biotage®  Selekt is a lean and compact automated flash system with two column channels, allowing you to run two separations in one instrument.  Users can easily switch between normal and reverse phase with the system automatically flushing the solvent lines for you! 

The in-situ sterilizable fermentor that is small in size, but large in results: Smallest in-situ sterilizable bench-top fermentor on the market Attractive choice in research and educational settings, especially for scale-up and screening purposes Range of options for both culture media mixing and gas dispersion allows for all kinds of aerobic cell cultures, anaerobic cell cultures, and even micro-carrier cultivations. S…

Axygen® Universal Tips are designed to fit a wide variety of single and multi-channel pipettors. These polypropylene tips are certified to be RNase-/DNase-free and nonpyrogenic. They are available in Maxymum Recovery, bevelled, Eppendorf-style, nonsterile, sterile, non-filtered, and other features for specialized applications. Flexible walls and a series of internal sealing rings ensure a secure fit with less force required t…

Flat bottom, with low evaporation lid. Individually wrapped, sterile, 50/case. Unique labyrinth lid, condensation rings, and deep-well design control contamination, reduce evaporation, and minimize edge effects.Reliable vacuum-gas plasma tissue culture treatment provides well-to-well and plate-to-plate consistency. Crystal-grade virgin polystyrene Nonpyrogenic Standard tissue culture (TC)-treated Convenient, peel-open medi…

White walled plates enhance luminescent signals and have low background luminescence and fluorescence Bottoms are 60% thinner than conventional polystyrene plates, resulting in lower background fluorescence and enabling readings down to 340nm Opaque walls to prevent well-to-well crosstalk Optically clear flat well bottom permits direct microscopic viewing Can be used for both top and bottom reading instruments Flat bott…

DRG develops and manufactures diagnostic ELISA test kits for use in clinical and research laboratories. The experience of our production team and management team guarantees high quality products, competitive prices and excellent customer service.

DeNovix Fluorescence Assay Kits and Fluorometers provide the greatest sensitivity and widest dynamic range. Selectively and accurately quantify DNA or RNA in the presence of common contaminants such as other nucleic acids or protein.

Vivid® CYP450 Screening Kits are high-throughput fluorescence-based assays for detection of enzyme-drug interactions and CYP450 inhibition. They provide an optimized method for studying isozyme-specific CYP450-drug interactions, metabolism, and inhibition. Vivid® CYP450 Screening Kits offer: Easy three-step procedure, "mix and read" format, reactions at room temperature or 37°C. Superior fluorescent properties and k…

Hear how DNA analysis helped unravel the mystery