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Cryo-electron microscopy (cryo-EM) allows the structural analysis of protein complexes flash-frozen in their near native states. You can now directly visualize not just large macromolecules but also smaller proteins complexes, including membrane proteins. This powerful technique can be used to complement traditional methods, such as X-ray crystallography (XRD) or nuclear magnetic resonance (NMR) for structure based drug discovery

A vital step in the cryo-EM workflow