ResourceSpectroscopy

Utilizing nanoscale IR spectroscopy to characterize biological samples in nanoscale detail

27 Jun 2023

The combination of atomic force microscopy (AFM) with infrared spectroscopy (IR) techniques, known as AFM-IR, allows for the chemical characterization of samples in nanoscale detail that would not be possible with the two techniques alone. AFM-IR spectroscopy, or nanoscale IR spectroscopy, has many applications including polymer characterization, pharmaceutical science, microelectronics, and life sciences. In this application note from Bruker, explore the principles and advancements of AFM-IR and see examples of AFM-IR applications in the life sciences, specifically for the nanoscale characterization of biological samples including proteins, structures within single cells, monolayers, and tissues.

Dimension IconIR

Bruker Nano Surfaces and Metrology

Bruker’s large-sample Dimension IconIR system combines nanoscale infrared (IR) spectroscopy and scanning probe microscopy (SPM) on one platform to deliver the most advanced spectroscopy, imaging, and property mapping capabilities available for academic researchers and industrial users. Incorporating decades of research and technological innovation, IconIR provides unrivaled performance based on and building off the industry-best AFM measurement capabilities of the Dimension Icon. 

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Anasys nanoIR3

Bruker Nano Surfaces and Metrology

The nanoIR3 is the latest generation nanoscale IR spectroscopy, chemical imaging, and property mapping system for both materials and life science applications. The system also provides IR-based chemical imaging to provide mapping of chemical variations of the feature of interest. Unique point spectroscopy capabilities provide both spectroscopy and chemical imaging with a single source.

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Utilizing nanoscale IR spectroscopy to characterize biological samples in nanoscale detail