Utilizing nanoscale IR spectroscopy to characterize biological samples in nanoscale detail

The combination of atomic force microscopy (AFM) with infrared spectroscopy (IR) techniques, known as AFM-IR, allows for the chemical characterization of samples in nanoscale detail that would not be possible with the two techniques alone. AFM-IR spectroscopy, or nanoscale IR spectroscopy, has many applications including polymer characterization, pharmaceutical science, microelectronics, and life sciences. In this application note from Bruker, explore the principles and advancements of AFM-IR and see examples of AFM-IR applications in the life sciences, specifically for the nanoscale characterization of biological samples including proteins, structures within single cells, monolayers, and tissues.