SelectScience
Join Free
ResourceSeparations

Using SEC-MALS-QELS to Analyse Molecular Properties of Chondroitin Sulfate

Waters | Wyatt Technology
3 Feb 2025

Chondroitin sulphate is started being used to treated people suffering arthritis, however Different preparations of the product have different molecular properties which are related to therapeutic effectiveness. In this application note, different chondroitin sulphate samples were compared using using size-exclusion chromatography (SEC) coupled to a DAWN multi-angle light scattering (MALS) and a WyattQELS quasi-elastic light scattering detector (QELS). The SEC-MALS-QELS method provides complete information about molar mass, radius and distributions of chondroitin sulfate.

Related products

Request Quote for All Products

DAWN™

Waters | Wyatt Technology

The DAWN is the premier Multi-Angle static Light Scattering (MALS) detector for absolute characterization of the molar mass and size of macromolecules and nanoparticles in solution, offering the highest sensitivity and widest range of molecular weight, size, concentration and optional features.

(124)

Links

Waters | Wyatt TechnologyCompany website

Tags

Size Exclusion ChromatographySize exclusion chromatography (SEC) is a liquid chromatographic technique used to separate and identify molecules based on their size, including polymers, proteins, nanoparticles & nucleic acid. SEC is further subdivided into gel filtration chromatography (GFC) and gel permeation chromatography (GPC) when an aqueous or organic mobile phase is used respectively. HPLC-based SEC systems and columns are available for analytical separation alongside SEC spin columns or filters to prep samples for many protocols. Find the best size exclusion chromatography equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.ChromatographyChromatography is a powerful technique used to separate and analyze components of mixtures based on their chemical properties. It is widely used in fields like biochemistry, pharmaceuticals, and environmental analysis. By exploiting differences in the interaction of substances with a stationary phase and a mobile phase, chromatography enables precise purification and quantification of compounds. Whether you're working with complex biological samples or industrial chemicals, chromatography is essential for obtaining high-quality results. Browse our peer-reviewed product directory to find the best chromatography systems, compare products, read customer reviews, and get pricing directly from manufacturers.Multi Angle Light Scattering

Related resources