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Understanding particle size, zeta potential, and stability in dispersion systems

1 Jun 2026

This whitepaper explains why particle size, zeta potential, and stability must be evaluated together to fully understand and control colloidal systems. Particle size defines the structural framework of a dispersion, while zeta potential provides insight into interparticle interactions and aggregation behavior. However, only direct stability measurements reveal how formulations evolve over time through processes such as sedimentation, flocculation, and phase separation. Discover how by integrating these complementary parameters, researchers can better predict product performance, improve formulation design, and ensure long‑term stability across applications in pharmaceuticals, food, and materials science.

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Particle CharacterizationParticle characterization instruments are used to determine particle size distribution, shape, surface area, zeta potential, density and porosity of particles and materials. Multiple tecchniques are available for determining particle size, shape and count including dynamic light scattering (DLS), laser diffraction, electrozone (Coulter technique), imaging particle analysis and single particle optical sensing. Determine the density of your material with a gas pycnometer or examine its surface area and porosity with gas adsorption analyzers and mercury porosimeters. Find the best particle characterization instruments in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Particle AnalysisMaterialsFormulationFormulation is the process of combining active pharmaceutical ingredients with excipients to produce a drug which is both stable and active.Nanotechnology