The Vanquish Platform: Major Improvement in Throughput and Resolution of Xanthones in Mangosteen Pericarp
31 Mar 2015Recently mangosteen pericarp, a fruit indigenous to Southeast Asia, has been proposed as a homeopathic therapy in the treatment of Parkinson’s disease. This application note describes an improved method to resolve many different analytes, including xanthones, within a mangosteen pericarp sample using the Thermo Scientific™ Vanquish™ UHPLC platform, providing enhanced throughput with better resolution and peak capacity.
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Thermo Scientific™ Acclaim™ 120 C18 Reversed-Phase LC Column
Thermo Fisher ScientificHigh Performance Reversed-Phase Columns for the Separation of Small Molecules. The Acclaim® 120 columns are designed for high resolution reversed-phase separations. The very high surface coverage and very low metal content together result in columns with excellent efficiencies. These columns provide exceptional performance for a variety of applications in the pharmaceutical, chemical, environmental, and food separations areas.Acclaim 120 C18 columns have high surface coverage, resulting in high-capacity columns. They are stable between pH 2 and 8 and available in 3 and 5 μm particles sizes, and 4.6, 3.0, and 2.1 mm-diameters, with an average pore diameter of 120 Å. Acclaim 120 C18 is also available in 2.2µm RSLC format (see Acclaim Rapid Separation LC columns section for more details). All phases are LC/MS compatible because of the low silica bleed that results from the stable bonding procedure.Acclaim® 120 C18 Reversed-Phase LC Column Features: Ultrapure silica with high-density bonding for low silanol activity Very high efficiencies for maximum resolution Reproducible manufacturing practices for reproducible column-to-column performance LC/MS compatible Column Details: Particle Size: 3, 5 µm Pore Size: 120 Å Length: 50, 100, 150, 250 mm ID: 2.1, 3.0, 4.6 mm