ResourceLife Sciences
Techniques to Improve MRM Assay Development Efficiency
Techniques to Improve MRM Assay Development Efficiency
28 Oct 2015More studies are using MRM and targeted proteomic strategies to quantify peptides/proteins of interest in biological samples. Scheduling the acquisition of MRM transitions of analytes in time greatly increases the number of peptides that can be monitored within a single assay. However, developing a robust time-scheduled assay for larger numbers of peptides can be time consuming. This poster demonstrates a range of techniques for improving the efficiency of assay development, allowing the optimizing of a large number of peptides at once.
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ProteomicsProteomics is the systemic bioinformatics study of proteins and amino acids, including their structure, size, function and identification. Tools used in proteomics include chromatography, blotting and gels, protein arrays, mass spectrometry and ELISA and associated analysis software. Analyzers and proteomic systems should be sensitive, high resolution, fast and may be automated for high-throughput.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.Targeted ScreeningPeptidesPeptides are short chains of amino acids that play key roles in biological processes, including signaling, immune responses, and enzyme regulation. Peptide research is critical in drug discovery, diagnostics, and vaccine development. Browse our peer-reviewed product directory to find the best peptides and peptide-related products, compare options, check reviews, and get pricing directly from manufacturers.Assay DevelopmentThe process of proving an assay to be sensitive with respect to the target is known as assay development. The assay should be able to characterize novel compounds and measure the potency of these compounds against a validated biological target.