Simultaneous analysis of 19 novel synthetic cannabinoids in urine using SPE and LC-MS/MS

30 Mar 2022

This application note outlines a solid-phase extraction (SPE) and LC-MS/MS method for the analysis of 19 synthetic cannabinoids in urine. These specific compounds were selected based on positivity rates from several key testing labs in the area. The use of UCT’s Styre Screen® HLD highly crosslinked polymeric SPE sorbent ensures efficient extraction of the synthetic cannabinoids while removing undesired matrix components and yielding clean extracts

Styre Screen® Extraction Columns

UCT, Inc.

Styre Screen® Extraction Columns contain an ultra clean, highly cross-linked styrene and divinylbenzene copolymer. The Styre Screen particles have an average particle size of 30 microns and a very high analyte capacity making them ideal for standard solid phase extraction applications. The increased analyte capacity means that less sorbent bed mass is needed which results in faster flow rates and less solvent use. Higher throughput and less solvent waste disposal translate into significant savings in both time and money. In addition, no conditioning steps are required for most analyte applications.   Styre Screen® Extraction Columns Advantages:   Copolymer allows for extraction of acids, neutrals and bases High and reproducible recoveries Clean extractions Highly cross-linked styrene/divinylbenzene polymer Reduction in sorbent mass Faster flow rates pH stable (1 to 14) Reduction in solvent use High sorbent capacity Methods for NIDA/SAMHSA 5 Drugs

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SELECTRA® HPLC Columns

UCT, Inc.

High purity, Type B, spherical silica support. 100A pore size. 1.8um, 3um, & 5um partical sizes. Variety of stationary phases.

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Select pH Buffer Pouches

UCT, Inc.

Select pH Buffer Pouches - UCT has developed a line of premeasured “ready-to-use” phosphate and acetate buffer pouches. These pouches contain the correct quantity of reagent to quickly and accurately prepare buffers at the correct pH and concentration to simplify solid-phase extraction methods.

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Simultaneous analysis of 19 novel synthetic cannabinoids in urine using SPE and LC-MS/MS