Simplified Method Development with the Tecan AC Extraction Plate™
2 Mar 2015The ideal sample preparation process for further analysis by techniques such as LC-MSMS should be simple, involve relatively few steps, produce a clean sample free from interfering matrix materials and, to increase analytical sensitivity, concentrate the analyte of interest. This technical note describes how to use the AC Extraction Plate as a method development tool for specific analytes for LC-MSMS analysis, by optimizing the three ‘pipette and shake’ steps.
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AC Extraction Plate™
TecanThe Tecan AC Extraction Plate* with TICE™ (Tecan Immobilized Coating Extraction) technology revolutionizes your sample preparation routine. The AC Extraction Plate is a 96-well, deep-well microplate, with each well having a proprietary TICE™ coating. TICE is a material with distinct absorptive properties, and this coating efficiently extracts specific small molecule analytes from aqueous solutions, releasing them when in contact with a suitable organic solvent. A simple pipette and shake sequence, with no filtration, centrifugation or solvent evaporation, is all that is required. The AC Extraction Plate is easily integrated into automated processes, making it a perfect match with Tecan’s Freedom EVO® liquid handling platform. AC Extraction Plate™ Features: Cost-effective – Simple pipette and shake workflow, without labor intensive centrifugation, filtration and solvent evaporation steps. Convenient and fast – Just unpack and start, no conditioning or other preparations needed. Highly reproducible – Pipette and shake routines are easily standardized and automated on a liquid handling platform, eliminating random errors and increasing consistency of results. * For research use only – not for clinical diagnostic applications