Screening Drugs and Toxic Compounds with LC-MS/MS: An Alternative to LC-UV for Research Toxicology Labs

This note presents the workflow and results obtained by using a UHPLC-MS system based on ultra-high pressure liquid chromatography and linear ion trap mass spectrometry technology. An evaluation is made of an LC-MS/MS method for the screening and semi-quantitation of drugs and toxic compounds in serum and urine matrices to determine if this approach can provide an alternative to REMEDi technology for research toxicology.