Robustness characterization of a quantitative whole blood assay using PaperSpray technology for clinical research

10 Nov 2023

This application note describes a method for quantitative and robust analysis of EDDP (2-ethylidene1,5-dimethyl-3,3-diphenylpyrrolidine), an opioid metabolite, in human whole blood for clinical research using the VeriSpray Paper Spray ion source coupled with a TSQ Quantis mass spectrometer.

VeriSpray™ PaperSpray Ion Source

Thermo Fisher Scientific

If you are dealing with a rising backlog of samples due to an insufficient chromatography-based solution, the Thermo Scientific VeriSpray PaperSpray ion source for mass spectrometry is a valuable alternative solution for MS analysis. This paper spray ionization technique provides direct sample analysis capability with your triple quadrupole mass spectrometer, eliminating the need for chromatographic based separation, simplifying your workflow and getting to results faster.

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TSQ Quantis™ MD Mass Spectrometer

Thermo Fisher Scientific

Achieve the sensitivity to perform routine quantitative analyses with remarkable speed and robustness. The Thermo Scientific™ TSQ Quantis™ MD Series mass spectrometer can be used by clinical diagnostic laboratories to meet their routine requirements for laboratory developed tests (LDTs). With Active Ion Management (AIM+) technology,the TSQ Quantis MD Series delivers confident quantitation for routine analyses of human specimens.

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Robustness characterization of a quantitative whole blood assay using PaperSpray technology for clinical research