Resolution Of Normal Phase Flash Chromatography Improved by Dry Samples
Resolution Of Normal Phase Flash Chromatography Improved by Dry Samples
20 Jul 2015This application note demonstrates that preparing dry samples using RediSep® solid load sample cartridges improves peak resolution over liquid injection techniques. When the compound and reaction by-products are over-diluted or dissolved in too polar a dissolving solvent, the compound peak broadens which leads to loss of resolution. The effects of band broadening and overlapping peaks were gauged using dual UV detection/monitoring.
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CombiFlash® Torrent
Teledyne LabsGet the ease of use and reliability provided by CombiFlash and RediSep for Development Scale purification with the CombiFlash Torrent Purification System from ISCO. One liter per minute flow rates rapidly purify up to 300 grams of sample. The 100 psi pumps accurately deliver a reproducible binary gradient. The CombiFlash Torrent system is designed to be flexible for a variety of large-scale purification needs, with various methods of sample introduction and collection.