Rapid LC-MS/MS method for monitoring bio-relevant levels of per- and polyfluoroalkyl substances (PFAS) in serum
22 Feb 2023In this application note, a quantitative workflow for the analysis of 22 per- and polyfluoroalkyl substances (PFAS) in serum was developed using a Gemini™ 3µm C18 column coupled with a SCIEX QTRAP® 6500+system. This targeted screening workflow provides a fast analytical method capable of accurately quantifying sub-nanogram per mL levels of PFAS in the human body.
Per- and polyfluoroalkyl substances are pervasive compounds used in a variety of industrial applications and found in a wide range of consumer products such as cookware, stain repellent, flame-retardant, and coatings. PFAS are considered environmental factors due to their persistent and bio accumulating nature. Bioaccumulation of PFAS in the human body resulting from environmental exposure is a growing public health concern. Recent studies have linked PFAS exposure to adverse health outcomes including:
- childhood health complications
- reduced kidney function
- thyroid disease
- hormone suppression
- decreased fertility
- increased cholesterol levels
- diabetes
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