Raman spectroscopy as a PAT tool for freeze/thaw applications in the biopharmaceutical industry

Biopharmaceuticals like monoclonal antibodies and vaccines require large-scale production and often off-site fill/finish steps, necessitating freezing and long-distance transport. However, freezing can impact product quality due to protein-ice interactions and freeze concentration effects.

Discover how Raman spectroscopy enables real-time, in situ monitoring of formulation components during freeze/thaw processes. Unlike conventional PAT tools that only track temperature, Raman combined with multivariate models provides localized, multi-analyte concentration data, offering a powerful solution to maintain product integrity throughout cold chain operations.