Native IEX-MS analysis of monoclonal antibodies using YMC Accura BioPro IEX SF columns

Whilst direct coupling of ion exchange chromatography (IEX) to mass spectrometry (MS) simplifies workflows and minimizes artefacts, the high salt concentrations typically used in IEX pose a challenge for MS compatibility.

Explore data from Roche Diagnostics that shows how using a 2.1 mm ID bioinert coated YMC Accura BioPro IEX SF column delivers superior resolution compared to a standard 4.6 mm ID PEEK column when coupled to MS. See how even from the first injection, sharper peaks, higher resolution, and optimal recovery are all delivered.