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Molnupiravir analyzed with an inverse gradient in HPLC

25 Mar 2022

This application note demonstrates how Molnupiravir can be analyzed using a simple “inverse gradient” HPLC method. This is offered as an orthogonal approach for a reversed phased method and will show various polar impurities not detected by reversed phase HPLC.

Cogent Diamond Hydride™ HPLC Columns

MicroSolv Technology Corp.

Cogent Diamond Hydride HPLC Columns are manufactured with TYPE-C™ silica (silica hydride) and a very small amount of carbon on the surface that adjusts the column hydrophobicity to an important level. This makes these columns have unique separation capabilities for scientists working in LCMS, metabolomics, bioanalytical, amino acids, organic acids, carbohydrates, and very polar small molecules.

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Molnupiravir analyzed with an inverse gradient in HPLC