Microchip CE-MS: A powerful tool for biotherapeutic characterization

30 Jun 2025

This eBook explores the power of the ZipChip microchip capillary electrophoresis–mass spectrometry (CE-MS) platform in simplifying charge variant analysis and accelerating biologic drug characterization. Featuring high-throughput, plug-and-play capabilities, ZipChip offers faster data acquisition and enhanced separation for therapeutic development.

ZipChip™

Repligen Corp

ZipChip enables seamless CE/ESI-MS workflow and provides fast CE separation, nano-spray level sensitivity to obtain high-resolution separation and mass spec data from characterization of intact proteins, antibody drug conjugates (ADCs), antibody subunits, peptides, and nucleic acids. 

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Microchip CE-MS: A powerful tool for biotherapeutic characterization