Measuring pA-level current flowing across artificial ion channels and nanopores using a reference 620 potentiostat

This application note outlines a method for measuring picoampere-level ionic currents through synthetic ion channels and nanopores embedded in planar lipid bilayers. Utilizing the Gamry Reference 620 potentiostat, the study demonstrates how to detect single-molecule conductance events, with emphasis on achieving high resolution and accuracy in low-noise environments. This setup is pivotal for advancing biosensing and molecular transport research.