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Mass-Directed Isolation of a Pharmaceutical Compound Using AutoPurify with an ACQUITY QDa Detector

30 Sept 2014

This application note demonstrates the feasibility of successfully isolating a synthetic pharmaceutical compound from a crude mixture using AutoPurify on an AutoPurification System configured with an ACQUITY QDa Detector.

ACQUITY QDa Mass Detector

Waters

The ACQUITY QDa® Mass Detector gives you certainty above all else. You can minimize the risk of unexpected coelutions or components and confirms trace components with the analytical confidence of mass detection. The ACQUITY QDa® Detector is a mass detector built around the needs of analytical scientists for chromatographic analysis. Robust, reliable and requiring no sample adjustments, it just integrates with your current LC, ACQUITY UPLC, ACQUITY UPC2 and purification systems. You'll enhance the analytical value and productivity of each analysis, and you won't need to run all the additional assays or time-consuming alternative techniques or even wait for results from specialist labs that cost your laboratory productivity. With the ACQUITY QDa® Detector, you now have information-rich mass spectral data to complement data from your current Waters® optical detectors, including the ACQUITY UPLC PDA, TUV, ELS, and FLR detectors, as well as the ACQUITY UPC² PDA Detector. This mass spectral information integrates seamlessly into the same workflow; routinely giving you more complete separation characterization. Features: Intuitive operation More information from every sample Effortless integration Increased efficiency Resolving complexity Applications: Food & Environment Life Sciences and Pharmaceuticals Chemical

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Waters Complete Line of Purification Products

Waters

TURNING YOUR EVERYDAY CHALLENGES INTO COMPETITIVE ADVANTAGES. When Waters is part of your purification process, positive change happens. Suddenly, everything from sample prep and purity to recovery becomes a streamlined process you can’t live without. Because you’re moving your sample through the process faster, with better results, purification is no longer an obligation. It’s an asset. A complete line of flexible, workflow solutions. Only Waters’ complete line of scalable and complementary SFE, Prep LC/LCMS, and Prep SFC/SFCMS solutions help you prepare for tomorrow by streamlining the purification process today. That means better sample purity and more workflow sanity from world-class, automated purification systems.

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Mass-Directed Isolation of a Pharmaceutical Compound Using AutoPurify with an ACQUITY QDa Detector