Identifying monoclonal antibodies with Quantum-Si’s next-generation protein sequencing technology

Identifying low-abundance monoclonal antibodies in a population of polyclonal antibodies can provide critical insights for diverse applications such as understanding disease mechanisms, disease diagnostics, vaccine development, therapeutic antibody discovery, and serological surveillance. Existing methodologies, despite their utility, come with significant disadvantages including high costs, complex procedures, and time-intensive workflows, which often limit their broad application. In this application note, Quantum-Si presents a method utilizing Quantum-Si’s next-generation protein sequencing technology on the Platinum^® instrument to successfully identify two low-abundance monoclonal antibodies in a population of polyclonal antibodies.