Hot-Melt Extrusion Compendium

Hot-melt extrusion (HME) can help achieve the needed high efficacy, overcome bioavailability issues of an active pharmaceutical ingredient (API), and tailor release profiles. HME is a straightforward technique in which solid dispersion of drug particles or molecules in a polymer matrix is achieved. Depending on the processing conditions and the chemical and physical properties of polymers and APIs, different types of dispersions are possible. Explore the versatility of HME, discover what happens when materials are heated, and learn how to design a solvent-free HME process and how to produce different dosage forms.