Thermo Scientific™ Pharma16 Twin-Screw Extruder
Rapidly develop pharmaceutical formulations and adopt continuous processing methods using the Pharma 16 Twin-Screw Extruder. It can switch between continuous hot melt extrusion (HME) or wet granulation (TSG) with ease. Optimize drug process development parameters with less time and effort than batch processes and easily scale-up to larger Thermo Scientific extruders using minimal amounts of expensive APIs and excipients.
Pharma 16 Twin-Screw Extruder
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The Pharma 16 Twin-Screw Extruder is ideal for pilot-scale, continuous HME or TSG processes used for research, development or production in the pharmaceutical industry. Companies can bring products to market faster and with high quality by developing a continuous process for solid dosage forms compared to a batch process. Effects of pilot-scale process conditions on drug formulations for drug delivery and pharmaceutics can easily be studied using the Pharma 16 Twin-Screw Extruder.
Pharma 16 Twin-Screw Extruder highlights:
- 2-in-1 process design – quickly disassemble parts for easy cleaning and process switching from HME to TSG.
- Simple continuous process integration - plug-and-play functionality with upstream and downstream process equipment (e.g., feeders, chill rolls, pelletizers, dryers, etc) simplifies production line design.
- Less optimization time, cost and effort – extruder process parameters are scaleable to larger Thermo Scientific extruders due to geometric similarity with minimal use of expensive ingredients.
Hot-Melt Extrusion Compendium
Hot-melt extrusion (HME) can help achieve the needed high efficacy, overcome bioavailability issues of an active pharmaceutical ingredient (API), and tailor release profiles. HME is a straightforward technique in which solid dispersion of drug particles or molecules in a polymer matrix is achieved. Depending on the processing conditions and the chemical and physical properties of polymers and APIs, different types of dispersions are possible. Explore the versatility of HME, discover what happens when materials are heated, and learn how to design a solvent-free HME process and how to produce different dosage forms.
