High-throughput modeling of IBD using human intestinal organoids
24 Mar 2024Inflammatory bowel diseases (IBD) involve chronic inflammation of the gastrointestinal tract, which is often challenging to model accurately using traditional mouse models. Recent advancements in organoid technology provide a promising alternative for disease modeling and drug screening. In this application note, Molecular Devices presents Gri3D®, a high-throughput and reproducible 3D culture platform, which addresses the limitations of traditional methods by allowing the growth of human rectal organoids from single cells with high scalability and reproducibility.
This application note was written in association with SUN bioscience.
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Gri3D® microwell plates
SUN bioscienceElevate your 3D research with Gri3D ® , the ready-to-use microwell plate designed for highthroughput, reproducible organoid culture. Based on a standard 96-microtiter plate, each well contains an ultra-dense U-bottom microwell array patterned in a cell-repellent hydrogel. Organoids are robustly generated in microwells, where they grow in suspension-like conditions and are located in the same imaging plane. A pipetting port on the side allows safe media exchange without microtissue loss.