High-pH tolerant HPLC separations using Inertsil Hybrid-C18 columns
11 Jun 2026This application-focused datasheet introduces the Inertsil Hybrid-C18 column, a high-performance HPLC stationary phase engineered for robust and reproducible separations across a wide pH range. Built on hybrid organic–inorganic silica technology, the column enables stable operation from pH 1 to 12, supporting both acidic and basic analytical conditions.
The resource highlights strong retention and peak shape for a broad range of analytes, including basic, acidic, and metal-coordinating compounds. It also demonstrates excellent batch-to-batch reproducibility and durability under high-pH conditions, making the column suitable for demanding LC and LC-MS workflows, including pharmaceutical and bioanalytical applications.
Resource details:
- Resource type: Brochure
- Page count: 8
- Read time: 12 mins
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Inertsil Hybrid-C18 LC Column
GL Sciences, Inc.Inertsil Hybrid-C18 is a high-pH resistant HPLC column that enables stable and reproducible separations across a wide pH range (1–12). Built with hybrid silica technology, it ensures excellent peak shapes even for basic analytes and provides superior lifetime compared to conventional C18 columns. Available in 1.7 µm, 3.5 µm, and 5 µm, it is ideal for LC-MS and method development.