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Glyburide and Metformin analyzed with HPLC

23 Mar 2022

In this application note, MicroSolv Technology Corporation demonstrates how the polar compound, Metformin, and the nonpolar compound Glyburide, can be retained on the same stationary phase. Depending on the mobile phase composition either Metformin or Glyburide can be retained longer.

Cogent Bidentate C18™ HPLC Columns

MicroSolv Technology Corp.

Cogent Bidentate C18™ HPLC Columns are manufactured with TYPE-C™ silica (silica hydride) and a straight chain C18 hydrocarbon bonded directly to the Silica Hydride surface with two separate points of attachment. The manufacturing of the Silica makes these columns virtually indestructible.

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Glyburide and Metformin analyzed with HPLC