Fabrication and characterization of nanofluidic devices for DNA optical mapping

Nanofluidic lab-on-a-chip devices for the analysis of single DNA molecules were fabricated and characterized using FIB-SEM. Direct FIB nanopatterning of silicon master stamps allows fast prototyping of nanochannels of different shapes, cross sections and depths.

In this application note, ZEISS demonstrates how the Crossbeam can be an extremely useful tool for research in the field of nanofluidics and single molecule detection.