Evaluating the Integration of CE, ESI and Mass Spectrometry for the Quantitative Analysis of Amino Acids in the Cationic Metabolome
18 Nov 2014Metabolomics can be defined as a comprehensive analytical approach for the study of all low-molecular-weight species present in a given biological system of interest. Development in recent years of an integrated interface technology composed of a capillary and emitter to form a seamless integrated process with electro-spray ionization, CESI, holds the promise of orders of magnitude in improvement of detections levels. This poster demonstrates the use of the CESI 8000 High Performance Separation - ESI Module from Sciex Separations for the quantitative analysis of amino acids in the cationic metabolome.
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CESI 8000 Plus system
SCIEXExtending the reach of your mass spectrometer. Mass spectrometry (MS) has become an indispensable technology for the analysis of compounds of biological interest. Our improvements in assay sensitivity and reduction in ion suppression reveal new information that is critical to your research, whether you’re characterizing a therapeutic protein, identifying the proteins that make up a specific proteome, analyzing post-transitional modifications, or studying a metabolomic fingerprint. We developed a new front-end separation and ionization technology called CESI, which combines the high efficiency and ultra-low flow of capillary electrophoresis (CE) with an integrated electrospray ionization source. This optimization of electrospray ionization (ESI) into the nanoflow region has been shown to greatly improve assay sensitivity and reduce ion suppression.