Embryonic Stem Cell Derived Cardiomyocytes, Cor.At® Cells, Tested on QPatch
22 Mar 2011This application note presents recordings of three essential cardiac currents; IK, ICa, and INa from Cor.At® cells obtained with the QPatch system. Axiogenesis has developed Cor.At® cells, cardiomyocytes derived from transgenic mouse embryonic stem cells. Differentiated stem cells, like Cor.At® cells, may be interesting for ion channel screening as they provide a more physiological relevant environment for the ion channel(s) under examination.
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QPatch HT and QPatch HTX
Sophion BioscienceThe QPatch HT and QPatch HTX enable high-throughput patch clamping with 48 parallel recording sites. Automated patch clamping with the same high quality afforded by conventional patch clamping can now be applied in all phases of ion channel drug discovery, including primary screening of focused compound libraries. • Up to 7000 data points per day • Screening and compound profiling • Multi-hole and single-hole mode (QPatch HTX) • Ligand- and voltage-gated recordings • Eight pipette liquid handling with intelligent scheduler • True gigaseals • Flow channels for solution exchange • Up to 50 liquid additions • User-friendly experiment execution • Unattended operation for several hours • On-board cell preparation • Elevator units for QPlate stacking • Elevator units for compound plate stacking • Cell clone screening feature • Multiple intracellular solutions testing feature • User friendly assay setup and quick data analysis