Development of a twin-column continuous chromatography oligo purification process
7 Mar 2023Peptide and Oligo synthesis technologies are well developed for large scale manufacturing of pharmaceutical materials. Isolation and purification is a critical step in these manufacturing processes, and almost always utilizes chromatography. Multi-column counter-current solvent gradient purification (MCSGP) is a twin column continuous chromatography process that has significantly more capability than a traditional single-step batch process. In this poster, YMC America shows that the product yield is greatly improved with MCSGP while avoiding many complications encountered with a batch process.
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Contichrom® CUBE
YMC America, Inc.The Contichrom CUBE is a benchtop continuous chromatography system for process development of (bio-)pharmaceuticals. The five-in-one functionality includes single-column and integrated batch chromatography, as well as twin-column counter-current processes such as capture (CaptureSMB®) for monoclonal antibodies and MCSGP for peptides and oligonucleotides. Additionally, the N-Rich® process functionality allows the rapid isolation of product-related impurities for CMC development.