ResourceLife Sciences
Developing a Robust Self-Optimizing MS/MS QTOF Workflow for De Novo Verification of Synthetic Peptides in Biopharmaceutical Applications
28 Apr 2016This poster presents a method optimized QTOF MS system with self-adapting deep sequencing MS/MS capabilities (InstantExpertise™) that allows facile pharmaceutical product verification of synthetic peptides. Bioactive peptides are common, widely used supplement products in pharma, biopharma, as well as nutritional industries. The synthesis of bioactive peptides with accurate amino acid sequences is pivotal to ensure correct biological activity; thus, methods that ensure accurate de novo verification as well as simultaneous impurity characterization are very important. This method combines high speed self-optimized MS/MS, accurate isotopic patterns, and high mass accuracy fragment data.
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Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer.
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