CHO Cells Stably Expressing Voltage Gated Potassium Channels Tested on the QPatch Platform
3 Apr 2011This application data shows data from CHO cells stably expressing KV1.5 tested on the QPatch platform. The voltage gated potassium channel KV1.5 is a homotetrameric protein present in the heart. It is a delayed rectifier, participating in the early phase of the heart action potential. Experiments were conducted to evaluate the IV-relationship of KV1.5 as well as dose-response for inhibitors. The response of KV1.5 to a known blocker was also tested.
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QPatch HT and QPatch HTX
Sophion BioscienceThe QPatch HT and QPatch HTX enable high-throughput patch clamping with 48 parallel recording sites. Automated patch clamping with the same high quality afforded by conventional patch clamping can now be applied in all phases of ion channel drug discovery, including primary screening of focused compound libraries. • Up to 7000 data points per day • Screening and compound profiling • Multi-hole and single-hole mode (QPatch HTX) • Ligand- and voltage-gated recordings • Eight pipette liquid handling with intelligent scheduler • True gigaseals • Flow channels for solution exchange • Up to 50 liquid additions • User-friendly experiment execution • Unattended operation for several hours • On-board cell preparation • Elevator units for QPlate stacking • Elevator units for compound plate stacking • Cell clone screening feature • Multiple intracellular solutions testing feature • User friendly assay setup and quick data analysis