Broad Scope Pesticide Screening in Food Using Triple Quadrupole GC-MS

This application note demonstrates two different ways to perform targeted and non-targeted screening of pesticides in one analytical run, by screening for 600 pesticides in selected reaction monitoring (SRM) mode or a smaller subset in selected reaction monitoring/ full scan (SRM/FS) mode. The increased accessibility of high selectivity GC-MS has enabled more generic sample preparation in pesticide testing, allowing consolidation of multiple analyte lists and matrices into one method. GC-MS/MS is well suited to multi-residue analysis in a diverse range of matrices. However, as the number of targeted compounds increases, the complexity of method optimization increases and analytical performance becomes compromised.