Biophysical and Pharmacological Profiling of Multiple Na V Subtypes on QPatch HT
29 Mar 2011In this application poster pharmacological and biophysical data is obtained on a panel of voltage-gated sodium channel subtypes expressed in cell lines. The QPatch cell clone screening feature and its direct integration with the QPatch Assay Software allows simultaneous testing of cell clones expressing the same gene(s) of interest, or simultaneous testing of a panel of ion channel subtypes or a group of ion channels (e.g. heart channels).
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QPatch HT and QPatch HTX
Sophion BioscienceThe QPatch HT and QPatch HTX enable high-throughput patch clamping with 48 parallel recording sites. Automated patch clamping with the same high quality afforded by conventional patch clamping can now be applied in all phases of ion channel drug discovery, including primary screening of focused compound libraries. • Up to 7000 data points per day • Screening and compound profiling • Multi-hole and single-hole mode (QPatch HTX) • Ligand- and voltage-gated recordings • Eight pipette liquid handling with intelligent scheduler • True gigaseals • Flow channels for solution exchange • Up to 50 liquid additions • User-friendly experiment execution • Unattended operation for several hours • On-board cell preparation • Elevator units for QPlate stacking • Elevator units for compound plate stacking • Cell clone screening feature • Multiple intracellular solutions testing feature • User friendly assay setup and quick data analysis