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Analytical development of a four‑stream multiplexed LC/MS method for the simultaneous determination of SDMA and ADMA

5 Oct 2020

This application note by Agilent demonstrates the development and confirmation of an analytical method for asymmetric and symmetric dimethyl arginine (ADMA and SDMA respectively).

StreamSelect LC/MS System

Agilent Technologies

LC/MS/MS is ideally suited for direct, rapid analysis of prepared biological samples. In high-throughput analytical environments , sample analysis times can be shortened by optimizing LC gradient, flow rate or column. A greater gain in throughput can be achieved by limiting the MS acquisition time to the portion where compounds of interest are eluted.

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Analytical development of a four‑stream multiplexed LC/MS method for the simultaneous determination of SDMA and ADMA