Analysis of genotoxic nitrosamines in losartan and ranitidine active pharmaceutical ingredients

The QTRAP 4500 system takes the legendary 4000 QTRAP platform and intelligently re-engineers it to set a new benchmark for reliable quantitation and library searching – with 100-fold more full-scan sensitivity over basic triple quadrupoles in the same class.  The LC-MS/MS workhorse is intelligently re-engineered. As one of the only triple quadrupole instruments with optional Linear Accelerator Trap technology, the QTRAP 4500 system enables powerful, unique workflows that deliver a new level of confidence in your data. High-confidence library searching and fast eQ electronics for UHPLC: The 4500 series uses proven eQ electronics delivering polarity switching speeds of 50 msec and scan speeds of 20,000 Da/sec, creating a potent solution for detecting unexpected contaminants. Combined with a single comprehensive library of thousands of QTRAP spectra for library matching, contaminants at the lowest levels can be confidently identified on a UHPLC time scale.   Features: Simultaneously quantitate MRMs and perform full scan library searches for non-targeted contaminants. Achieve a 100X increase in full-scan sensitivity over triple quads providing an enhanced level of confidence for forensic toxicology applications. Boost selectivity with quantitative MRM3 workflows – and reduce the need for extensive sample cleanup or labor-intensive chromatography methods. Obtain comprehensive peptide sequence confirmation and simplify MRM assay development for peptide quantitation.