Analyses of antibody drugs using ultra high performance liquid chromatography

Antibody drugs, such as monoclonal antibodies (mAbs) and antibody-drug conjugates (ADCs), are known to offer high therapeutic efficacy and reduced side effects due to their specificity and affinity for target molecules. However, because these biopharmaceuticals are manufactured using animal cells, ensuring their structural homogeneity can be challenging. Discover how the ultra high performance liquid chromatography (UHPLC) system, Nexera XS inert, compares to other chromatography techniques including size-exclusion chromatography (SEC), ion exchange chromatography (IEX), and hydrophobic interaction chromatography (HIC), for quality control in the analyses of mAbs and ADCs.