ResourceDrug Discovery & Development
Advances in native binding assays
12 May 2026This resource highlights recent advances in native binding analysis using isothermal titration calorimetry, demonstrating how the technique enables direct, label‑free measurement of binding affinity and full thermodynamic profiles. Using the Affinity ITC system, the study shows how improvements in automation, mixing efficiency, and data analysis allow faster screening, improved reproducibility, and enhanced insight into binding interactions, supporting applications in drug discovery, biomolecular research, and high‑throughput screening workflows.
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Isothermal Titration Calorimeter Affinity ITC
TA Instruments - Waters LLCThe Affinity ITC provides unmatched sample reproducibility with the highest sensitivity, innovative technology, and industry-proven reliability.
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CalorimetryCalorimetry is a technique used to determine the heat released or absorbed in a chemical reaction. Calorimeters can be categorized into bomb calorimeters, constant pressure calorimeters, differential scanning calorimeters, isothermal titration calorimeters, X-ray microcalorimeters, heat-loss calorimeters, and high-energy particle calorimeters. The choice of calorimeter depends on the application.isothermal titration calorimetryHigh ThroughputHigh throughput experiments allow the simultaneous processing of several samples. This parallelization reduces the cost per experiment and increases reproducibility and output volume of data.Biomolecular Interactions