A Novel Sample Preparation Device for Improved Phospholipid Removal in Bioanalytical Assays
16 Mar 2011In this application note Ostro Sample Preparation Products are analysed as a novel solution for the rapid and simple cleanup of phospholipids in biological samples prior to LC/MS/MS analysis. If not removed from the sample, phospholipids can build up on analytical columns, elute at unpredictable times in subsequent injections, and negatively impact assay robustness in a number of different ways.
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ACQUITY UPLC BEH Columns
WatersIn 2004, Waters revolutionized liquid chromatography with the introduction of the ACQUITY UPLC System. At the heart of the system was Waters second generation hybrid, the Ethylene Bridged Hybrid (BEH) particle. In 2005, BEH Technology preparative particle sizes (2.5, 3.5, 5 and 10 μm) with the introduction of XBridge between HPLC and UPLC Technology platforms. BEH Technology particles offer: Excellent peak shape and efficiency for basic analytes A rational array of chromatographic selectivity Improvements in chemical stability at mobile phase extremes, particularly at elevated pH