ResourceDrug Discovery & Development
A new approach to detecting drug-excipient incompatibility
9 Mar 2026Thermal stability is a critical parameter in understanding protein behavior, yet traditional melting analyses can overlook subtle structural transitions. Explore the concept of apparent melting as a more sensitive approach for detecting conformational changes under varying conditions. Discover how this method enhances resolution, improves data interpretation, and supports more reliable stability assessments.
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CalorimetryCalorimetry is a technique used to determine the heat released or absorbed in a chemical reaction. Calorimeters can be categorized into bomb calorimeters, constant pressure calorimeters, differential scanning calorimeters, isothermal titration calorimeters, X-ray microcalorimeters, heat-loss calorimeters, and high-energy particle calorimeters. The choice of calorimeter depends on the application.Pharmaceutical Excipients