A customized XF workflow for detection and characterization of mitochondrial toxicity
22 Feb 2023Learn more about the Agilent Seahorse XF Mito Tox Assay, a customized XF solution that allows the detection and quantitative assessment of compounds eliciting mitochondrial toxicity. This application note provides proof of concept and examples for compound screening, dose-response experiments using the XF Mito Tox assay, and interpretation of resulting data using the Mito Tox Index (MTI). It also presents a discussion of strategic assay design, performance metrics, and specific cases when using the XF Mito Tox Assay.
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Seahorse XF Pro Analyzer
Agilent TechnologiesMeasure mitochondrial respiration, glycolysis, and ATP production rates in live cells in a 96-well forma t, providing a system-level view of cellular energy metabolism and mitochondrial health. It combines enhanced sensitivity and data consistency with intuitive software and advanced data analytics, enabling users to streamline assay workflow from start to finish and generate and interpret metabolic data easily.