Combinatorial Chemistry Products & Reviews

The LlaVHHL-2 Llama Naïve Single Domain Antibody Library is a state-of-the-art resource for efficient, high-quality antibody screening. Designed to meet the diverse needs of researchers, this library provides access to a rich pool of sdAbs derived from llama naïve antibody genes.

Tailored formulation and conjugation for nucleic acids and biologics, covering LNPs and alternative carriers, ligand-directed strategies (e.g., GalNAc), and full characterization and process development to enhance stability, targeting, and potency with documentation for scale-up and regulatory needs.

The Phage Display AlVHHL-2 Alpaca Single Domain Antibody Library excels due to its vast library size and significant genetic variety produced from multiple alpacas. The combination of broad genetic diversity and single-domain antibodies delivers precise solutions for complex scientific challenges that standard antibody libraries find difficult to address.

Custom DNA/RNA oligonucleotide synthesis with broad modification choices (PS, 2′-OMe, 2′-F, LNA, GalNAc, dyes/biotin), multiple scales and purifications, and analytical QC. Includes design consultation and documentation to support research, translational studies, and conjugation-ready formats.

Creative Biolabs provides screening services for the CaVHHL-S2 Camel Synthetic Single Domain Antibody Library but does not sell the library directly. Our advanced M13 pIII fusion phage display technology combined with high-throughput screening platforms enables clients to rapidly identify ideal antibody candidates while resolving issues like extended screening durations and the detection of low-affinity antibodies.

Integrated ASO development from sequence design and chemistry selection to preclinical PK/PD, safety, delivery (e.g., GalNAc), and CMC—supporting gapmer and steric-blocker approaches to advance programs efficiently toward IND.

The Phage Display HuVHHL-S1 Humanized Synthetic Single Domain Antibody Library serves as a leading resource to expedite the discovery of high-quality antibodies with exceptional specificity. Our library makes efficient identification of optimized drug candidates possible through the use of advanced humanization and randomization technologies, together with a strong high-throughput screening platform.

Comprehensive circRNA services including design, circularization (e.g., ribozyme/intron-mediated), purification, and analytics to deliver stable, translation-competent RNA with improved durability—supported by process development for research and translational programs.

The HuScL-6 Human Single Chain Antibody Library is a state-of-the-art resource for efficient, high-quality antibody screening. Designed to meet the diverse needs of researchers, this library provides access to a rich pool of scFv antibodies derived from human naïve antibody genes.

End-to-end viral vector design and construction covering vector/serotype selection, expression-cassette optimization, cloning, packaging, purification, and QC. Supports AAV, lentivirus, adenovirus, HSV, vaccinia, and baculovirus with scalable production and documentation for in vitro/in vivo studies and IND-enabling work.

Twist Multiplexed Gene Fragments are double stranded gene fragment sequences of up to 500 base pairs in length that are delivered as a pool instead of one fragment per well matrix.

Vapourtec offers a range of world class peptide synthesizer systems offering fast flow solid phase peptide synthesis from 0.05 mmol to 30 mmol.

ISOAPI-D™: Built Specifically for the Next Generation of Deuterated Reagents in Pharmaceutical Development

Stable Isotope-labeled Gases and Packaging Options

Stable Isotope-Labeled Materials for Peptide Synthesis

IDEAL FOR ORGANIC AND AQUEOUS SYNTHESES

Assay (GC): ≥ 99.0%

Sino Biological provides comprehensive ADC development and production solutions, covering early discovery, process development, preclinical studies, and clinical research, to fully support clients throughout the ADC development process.

GenScript provides targeted lipid nanoparticle (LNP) formulation services for precision RNA delivery applications, including immune cell engineering, in vivo CAR-T, gene editing, and therapeutic development. By combining optimized LNP formulations with ligand-mediated targeting strategies, the GenScript platform is designed to improve delivery efficiency, targeting specificity, and translational potential for advanced RNA ther…

Stable Isotope-labeled Elements and Compounds

SynPhase Lanterns are the latest generation of grafted products optimized for small organic molecule and peptide synthesis.The SynPhase Lantern is cylindrical in appearance and is available in three different sizes, L-series, D-series and A-series with physical dimensions as shown in the table below. These properties make the SynPhase Lantern compatible with a wide range of reaction vessels and synthesizers.

HBPS provides both research and cGMP monoclonal antibody production.

Do you need interesting and unique building blocks for you small molecule combinatorial program? If you look at our 3500 In-House designed and externally acquired building blocks (from contract chemists) we are sure you will agree that this is a unique collection. These building blocks cannot be found in the major catalogues.