Crown Bioscience’s preclinical biomarker services help identify, validate, and analyze biomarkers across diverse in vitro and in vivo cancer models. Using multi-omics platforms and expert bioinformatics, these services support drug mechanism studies, patient stratification, and companion diagnostic development to guide oncology drug discovery.
Our Metabolite Identification service employs HRMS /LC-MS/MS to decode degradation pathways of antisense oligonucleotides (ASOs), siRNAs, and modified variants, identifying chain-shortened metabolites (5’/3’ cleavage), phosphorothioate changes (desulfurization, inversion) and base/nucleotide alterations (deamination/depurination). Through plasma/tissue/cell analysis, we reveal metabolic stability, biodistribution, and exonucle…
Our Metabolite Identification service for Antibody-Drug Conjugates (ADCs) applies immuno-capture and HRMS to detect payload-containing catabolites, linker cleavages, and biotransformations in biological samples. This targeted assay quantifies free payloads, metabolites, and intact conjugates, assessing stability and off-target risks. Essential for ADC development, it informs payload design and pharmacokinetics, ensuring compli…
PDX Models Empower your research with models that reflect today’s patients and treatments.
Unlock deeper insights into tissue organization and cellular interactions with Crown Bioscience’s spatial biology and digital pathology services, featuring advanced imaging, automated analysis, and high-throughput biomarker screening for applications in cancer research, immunology, and more.
Explore your translational research with Crown Bioscience’s comprehensive genomics services—offering PCR/qPCR, next-generation sequencing, and advanced bioinformatics to deliver high-quality, reproducible data for biomarker discovery and drug development.
Our Cassette and Discrete PK Study service evaluates pharmacokinetic profiles of small molecules in key preclinical species: rat, mouse, dog, and monkey. It uses cassette dosing for high-throughput screening of multiple compounds simultaneously and discrete dosing for precise individual assessments for ADME parameters. This aids in early drug optimization, predicting human PK, and ensuring regulatory compliance for safer candi…
Charles River is a preclinical drug discovery CRO that manages your project from drug target discovery to hit identification, hit-to-lead, and lead optimization
QPS Global Custom-Built Regulatory Services Can Transform Clinical Trials. QPS Global Regulatory Affairs (GRA) service offerings focus on helping pharmaceutical, biotechnology, and medical device companies to develop custom-built research solutions that forge expedited regulatory pathways from discovery to global commercialization and onwards through product lifecycle support.
Moving quickly and safely through Phase I/IIa trials is critical to successful drug development. The QPS Phase I research facilities feature more than 550 beds across six strategically located facilities on three continents. QPS is well known for its success in first-in-human clinical trials. All Phase I sites are staffed by expert clinical pharmacology teams that routinely conduct hundreds of phase I/IIa studies annually.
At QPS, we realize that in today’s late stage drug development space you face many challenges. With our deep experience and broad global presence, QPS is in an excellent position to offer solutions to all of the above needs. With its site management & monitoring teams operating from 30 locations on three continents (Asia/Pacific, USA, and Europe), QPS has become a new strong player in Phase II/IV clinical research services.
Alturas Analytics is a CRO specializing in preclinical and clinical bioanalysis
Cresset Discovery is a premier computational chemistry CRO with a proven track record delivering high impact drug discovery projects. From ideation to synthesis and biological results, their expert CADD scientists are the best at what they do. Working alongside you from the ground up, they apply the best in silico techniques, and give expert advice and guidance, to accelerate your assets through the pipeline.
Svar CRO Services provides direct value through an extensive toolbox of in-house products, scientific expertise, and end-to-end customizable solutions – everything to ensure the success of your drug development program.
