Products & Reviews

Chemicon's S1P2 membrane preparations are crude membrane preparations made from our proprietary stable recombinant cell lines to ensure high-level of GPCR surface expression; thus, they are ideal HTS tools for screening of S1P2 interactions with its ligands. The cell line exhibits EC50 of 7.2nM for S1P in a GTPγS binding assay.

EMD Millipore's S1P3 membrane preparations are crude membrane preparations made from our proprietary stable recombinant cell lines to ensure high-level of GPCR surface expression; thus, they are ideal HTS tools for screening of S1P3 interactions with its ligands. The membrane preparation exhibits EC50 of 1.7nM for S1P in a GTPγS binding assay.

The RNAscope™ and BaseScope™ Assays are based on the proprietary RNAscope Technology enabling RNA target expression analysis within intact cells and tissues with high sensitivity and specificity. Using proprietary ACD RNAscope Probe Design Pipeline, we provide double "Z" oligo probes designed to hybridize to your specific RNA target of interest.

Determine if a gene product or compound activates pathways leading to specific enhancers with our PathDetect Cis-Reporting Systems.  When PathDetect cis-reporting and expression plasmids encoding your gene of interest are co-transfected into mammalian cells, increased reporter activity indicates transcription activation and involvement of your gene product in the pathway leading to the enhancer element. For ultimate flexibi…

An automated cell imaging and isolation platform built to streamline cell line development (CLD). With GLP and GMP compliant documentation and traceability. Assess productivity faster, reduce scanning times, and simplify operations with a maintenance-free design. Advanced sensitivity for low-expression targets, you get clear, reliable imaging to rapidly identify and document your best clones.

The pESC vectors are a series of epitope-tagging vectors for expression of eukaryotic genes in the yeast S. cerevisiae.  Each vector contains GAL1 and GAL10 yeast promoters in opposing orientations. With these vectors you can introduce one or two cloned genes into a yeast host strain under the control of an inducible promoter.

Build tomorrow’s cell therapies and cell-based disease models using TARGATT™ Human Induced Pluripotent Stem Cell (hiPSC) Kits. With the ability to efficiently and site-specifically insert 20+ kb of DNA (more with nested reactions), TARGATT™ hiPSC technology enables expression of large proteins and multi-protein complexes in hiPSC-derived human cell lines.

EMD Millipore's S1P5 membrane preparations are crude membrane preparations made from our proprietary stable recombinant cell lines to ensure high-level of GPCR surface expression; thus, they are ideal HTS tools for screening of S1P5 interactions with its ligands. The membrane preparations exhibit EC50s of 2.4 nM for S1P in a GTPγS binding assay.

In breast cancer STC2 is induced by estrogen and STC2 expression levels correlate with levels of estrogen receptor. STC2 function in different cancers may involve regulation of cell proliferation, neoplastic transformation and endothelial invasion. STC2 also plays a role in epithelial-mesenchymal transition by activation of MAPK/ERK signaling in hypoxic ovarian cancer cells. 

This generic E.coli Host Cell DNA ELISA kit is intended in determining the presence of Host Cell DNA contamination in various products that are manufactured through recombinant expression in E.coli. The kit has been validated successfully for testing of in process and final product in variety of products regardless of growth and purification process.

CRISPR Screening Services Horizon offers comprehensive CRISPR screening services from screen design and cell line selection to sophisticated bioinformatics analysis of the screen results. Our best-in-class CRISPR KO (knockout), CRISPRi (interference) and CRISPRa (activation) screening platforms can significantly advance our customers’ drug development programs by offering the highest quality and highest confidence in their…

Determine if a gene product or compound activates pathways leading to specific enhancers with our PathDetect Cis-Reporting Systems.  When PathDetect cis-reporting and expression plasmids encoding your gene of interest are co-transfected into mammalian cells, increased reporter activity indicates transcription activation and involvement of your gene product in the pathway leading to the enhancer element  

Determine if a gene product or compound activates pathways leading to specific enhancers with our PathDetect Cis-Reporting Systems.  When PathDetect cis-reporting and expression plasmids encoding your gene of interest are co-transfected into mammalian cells, increased reporter activity indicates transcription activation and involvement of your gene product in the pathway leading to the enhancer element  

Determine if a gene product or compound activates pathways leading to specific enhancers with our PathDetect Cis-Reporting Systems.  When PathDetect cis-reporting and expression plasmids encoding your gene of interest are co-transfected into mammalian cells, increased reporter activity indicates transcription activation and involvement of your gene product in the pathway leading to the enhancer element.

Determine if a gene product or compound activates pathways leading to specific enhancers with our PathDetect Cis-Reporting Systems.  When PathDetect cis-reporting and expression plasmids encoding your gene of interest are co-transfected into mammalian cells, increased reporter activity indicates transcription activation and involvement of your gene product in the pathway leading to the enhancer element.

Determine if a gene product or compound activates pathways leading to specific enhancers with our PathDetect Cis-Reporting Systems.  When PathDetect cis-reporting and expression plasmids encoding your gene of interest are co-transfected into mammalian cells, increased reporter activity indicates transcription activation and involvement of your gene product in the pathway leading to the enhancer element.

Determine if a gene product or compound activates pathways leading to specific enhancers with our PathDetect Cis-Reporting Systems. When PathDetect cis-reporting and expression plasmids encoding your gene of interest are co-transfected into mammalian cells, increased reporter activity indicates transcription activation and involvement of your gene product in the pathway leading to the enhancer element.

Determine if a gene product or compound activates pathways leading to specific enhancers with our PathDetect Cis-Reporting Systems. When PathDetect cis-reporting and expression plasmids encoding your gene of interest are co-transfected into mammalian cells, increased reporter activity indicates transcription activation and involvement of your gene product in the pathway leading to the enhancer element.

Determine if a gene product or compound activates pathways leading to specific enhancers with our PathDetect Cis-Reporting Systems. When PathDetect cis-reporting and expression plasmids encoding your gene of interest are co-transfected into mammalian cells, increased reporter activity indicates transcription activation and involvement of your gene product in the pathway leading to the enhancer element.

Determine if a gene product or compound activates pathways leading to specific enhancers with our PathDetect Cis-Reporting Systems. When PathDetect cis-reporting and expression plasmids encoding your gene of interest are co-transfected into mammalian cells, increased reporter activity indicates transcription activation and involvement of your gene product in the pathway leading to the enhancer element.

Determine if a gene product or compound activates pathways leading to specific enhancers with our PathDetect Cis-Reporting Systems. When PathDetect cis-reporting and expression plasmids encoding your gene of interest are co-transfected into mammalian cells, increased reporter activity indicates transcription activation and involvement of your gene product in the pathway leading to the enhancer element.

Determine if a gene product or compound activates pathways leading to specific enhancers with our PathDetect Cis-Reporting Systems. When PathDetect cis-reporting and expression plasmids encoding your gene of interest are co-transfected into mammalian cells, increased reporter activity indicates transcription activation and involvement of your gene product in the pathway leading to the enhancer element.

Determine if a gene product or compound activates pathways leading to specific enhancers with our PathDetect Cis-Reporting Systems. When PathDetect cis-reporting and expression plasmids encoding your gene of interest are co-transfected into mammalian cells, increased reporter activity indicates transcription activation and involvement of your gene product in the pathway leading to the enhancer element.

The Lambda ZAP II vectors combine the high efficiency of lambda vector systems with the versatility of plasmid systems. They enable prokaryotic expression of your gene of interest under control of the lac promoter. In vivo excision of the Lambda ZAP II vector yields the pBluescript SK- vector, which is a high-copy number pUC-based phagemid.  

The Lambda ZAP II vectors combine the high efficiency of lambda vector systems with the versatility of plasmid systems. They enable prokaryotic expression of your gene of interest under control of the lac promoter. In vivo excision of the Lambda ZAP II vector yields the pBluescript SK- vector, which is a high-copy number pUC-based phagemid.