Products, services, reviews and techniques used in the identification and validation of the disease-causing target genes and proteins.
With the recent surge of T cell–based immunotherapies, more researchers are taking interest in these specialized immune cells, particularly with respect to the development of chimeric antigen receptor T cell (CAR-T) therapies. Whether you’re developing a CAR-T therapy, another type of T cell immunotherapy, or working with other immune cell types, we can help you move from research to the clinic and beyond. Our cell culture med…
The recent advances in cell and gene therapy have led to the need for more cost-effective and scalable lentiviral vector (LV vector) manufacturing platforms. Lentiviral vector gene therapy is now widely used because of its use in advanced clinical trials and regulatory-approved therapies in combination with technological improvements in characterization and safety profiling. As a world leader in serving science, the innovative…
The iLite® Fc Effector Reporter Gene Bioassays Portfolio offers a variety of reporter gene cell lines and target cells that can be used in MOA-reflective assays to measure the Fc effect of antibodies and other biologics that specifically bind and activate Fc receptors. Using a Luciferase reporter gene system offers a convenient and powerful way of measuring antibodies' in vitro efficacy in triggering ADCC and ADCP.
In diagnosis of Rheumatoid Arthritis (RA), the measurement of anti-CCP is integral. People who test positive for Anti-CCP, are very likely to develop or have already developed RA, but not all who have RA, necessarily develop anti-CCP. Early detection of RA is crucial for reducing tissue damage.
Specifically formulated for superior expansion of human natural killer (hNK) cells for cell therapy applications
First commercially available, defined, serum-free medium (SFM) for the proliferation and/or manipulation of T cells and dendritic cells manufactured in compliance with cGMP
Classical Dulbecco’s phosphate buffered saline that contains calcium and magnesium but no phenol red
Animal origin free (AOF) dipeptide alternative to L-glutamine, with increased stability that improves cell health
GMP-manufactured Cas9 protein for clinical research
Next-generation CRISPR Cas9 protein engineered to deliver maximum editing efficiency
a revolutionary mass spectrometry technology that defines a new architecture for the front end of a mass spectrometer.
The Thermo Scientific™ Orbitrap Exploris™ MX detector is the perfect fit for routine mass monitoring. It adds unprecedented simplicity, robustness, and HRAM-enabled confidence to multi-attribute method (MAM) workflows. In addition to operational productivity, integrated Thermo Scientific™ Chromeleon™ CDS software provides superior MS data-processing tools and comprehensive controls for regulated labs.
High optical-quality glass bottom, black microplates are ideal for performing high content cell-based assays using imaging systems. The glass bottom provides a flat and optically clear surface that reduces autofocus time, increases throughput and is ideal for cell growth.
DISC™ devices give scientists enhanced control over growth factor levels in their cultures. Adding one DISC™ provides a stable level of native growth factors over 1-2 weeks. DISCs™ reduce your cell culture costs and provide robust, high-quality cells.
The FiberCell Systems Duet Pump provides flexible flow rate support for all of the FiberCell Systems hollow fiber bioreactor cartridges.
ClonExpress ® technology is a simple, fast and efficient DNA seamless cloning technology, which can clone the insert into any position of any vector.
VAHTS Universal V8 RNA-seq Library Prep Kit for Illumina is specially designed for the preparation of transcriptome libraries for Illumina platform. The kit is universal and suitable for RNA library construction of RNA that have been obtained by Poly(A)-based mRNA enrichment or rRNA depletion. The kit contains two types of cDNA 2nd Strand synthesis buffer, which can be chosen for library construction for non-stranded or stran…
The T7 Endonuclease Detection Assay is a well-known method for detecting genome editing events from CRISPR, Zinc-finger nuclease, and TALEN gene targeting. Originally identified from Escherichia coli bacteriophage, the T7 endonuclease can cleave mismatched heteroduplex DNA, Holliday junctions, branched DNA, and cruciform DNA.
All-in-one, ready-to-use Cas9 and guide RNA (gRNA) expression plasmids for use with monocots and dicots.
CRISPR/Cas9-mediated recombineering is the most powerful bacterial genome engineering method to date. In addition, Cas9-mediated recombineering overcomes the dependence on a second recombination step, avoids the creation of destabilizing scar sites, can be used in multiplexing, and is less time-consuming than previous protocols.
This Lentiviral Packaging Mix is an optimized formulation of two plasmids expressing the key HIV packaging genes and a heterologous viral envelope gene.
Universal negative control CRISPRs have been designed not to recognize any sequence in the human, mouse or rat genome.
Compare and contrast the features of a wide variety of guide RNA (gRNA) and Cas9 products for in vitro and in vivo CRISPR experiments. Select the best formats for your mammalian or plant applications: SygRNA ® synthetic gRNA, plasmid DNA, lentiviral particles, and proteins.
