Drug discovery > Target Discovery Products & Reviews

Cryoprotective media for mammalian cells. Contains serum, size: 50ml.

DMEM:Hams F12 (1:1) ready-to-use supplemented with L-glutamine, HEPES and 5 % FBS. Shelf life 8 weeks from date of manufacture.

RPMI 1640 medium ready-to-use, with serum supplemented with L-glutamine and 10% FBS.

Cell Detachment Solution. Cell Culture grade. Ready-to-use.

RPMI 1640 medium, basic, without serum (MG-70a) supplemented with L-glutamine. Addition of serum or other supplementation required.

Cryoprotective medium, serum free, Animal-Component free, for mammalian cells, contains 5% DMSO

Cell line authentication for Human and/or Murine cells. Method: STR (Short Tandem Repeats). Analysis of the gDNA sent by the customer and comparison with online data bases.

Hams F12 medium ready-to-use, with serum, supplemented with L-glutamine and 10% FBS. Shelf life 8 weeks from date of manufacture.

Cell line authentication for Human and/or Murine cells

Sigma-Aldrich ® one-part sgRNA and two-part crRNA:tracrRNA systems accelerate genome editing with Cas9 protein, mRNA, or established Cas9 expressing cell lines. Our guides are compatible with a variety of delivery methods including microinjection, electroporation, and lipofection.

With the largest portfolio of Cas9 proteins available, Merck make it easy to find the perfect nuclease for your gene editing experiment.

The largest and most validated shRNA collection from the RNAi consortium (TRC). Merck's unique shRNA formats leverage the discovery potential of the trusted and proven TRC shRNA collection. When you partner with them, you gain access to their world class lentiviral production expertise and the formats and specifications for RNAi knockdown experiments at any scale.

This guideline describes the design, development, and validation of quantitative assays for proteins and peptides by mass spectrometry.

For transient gene repression with CRISPR-level specificity

Horizon's CRISPRi guide RNA in an easy to deliver lentiviral format

Horizon's proprietary dCas9-SALL1-SDS3 CRISPRi repressor in mRNA format

Horizon's proprietary dCas9-SALL1-SDS3 CRISPRi repressor in lentiviral particle format

A direct and efficient set of tools to study a gene’s function by transcriptional interference in its native context

Bioinformatics and Protein Array Services

Profiling against cancer antigens. Using the CTA Protein Array, Sengenics can quantify autoantibodies against more than 200 clinically relevant cancer testis antigens. These are tumor antigens normally expressed in germ cells but not in adult somatic tissues. In cancers, this regulation can be disrupted, resulting in CTA expression in tumors. The CTA array is ideal for research related to cancer immunotherapy.

Cancer drug screening and discovery. The OncoRex p53 Cancer Array provides a biologically relevant screening tool since all p53 variants are correctly folded and functional using the patented KREX ® protein folding technology. Using the array, Sengenics can screen your therapeutic antibodies and protein binding compounds against more than 100 p53 wildtype and mutant variants by measuring their impact on DNA binding as a func…

Combining the sensitivity of a fluorescence-based assay with a microplate format enables a rapid, quantitative readout suitable for high-throughput analysis. In a microplate well, the fluorescent signal can be generated within whole cells, in cell lysates, or in purified enzyme preparations and may then be analyzed by measuring fluorescence intensity from the well without the need for cellular imaging.

High-throughput online automated sample concentration LC-MS solution for water and beverage analysis

Automate complex and time-consuming sample preparation workflows integrated with LC-MS analysis

SU10 is a nanopipette-based tool for efficient and controlled delivery of material (such as CRISPR Cas9 complex, RNA, proteins) into the nucleus or cytoplasm of single cells in a highly automated manner. The CRISPR Cas9 complex can be delivered directly into the nucleus of a specific target cell in a minimally invasive manner through the utilized glass pipette in nanometer range (approx.100 nm).