Drug discovery > Pre-Clinical Development Products & Reviews

As the world's largest private repository of human cerebrospinal fluid, BioIVT’s Center for NeuroExcellence offers 35,000+ healthy and 113,000+ diseased donor samples allowing for comparative studies and precise control matching. The samples are ethically collected following strict quality standards and feature detailed clinical data and matching blood, plasma, or sera.

With decades of drug metabolism, drug-drug interactions (DDI) and related expertise, BioIVT’s experts can provide you with the right studies to understand the properties and potential risks of your compound when it’s most critical for your program.

Inotiv offers industry leading, small and large animal surgical services.

Radio-telemetry monitoring of blood pressure, heart rate, ECG, temperature, activity

Accelerate precision oncology with Crown Bioscience’s high-quality human biospecimens—comprehensive, clinically annotated samples including tumor tissue, plasma, and PBMCs, optimized for multi-omics research and biomarker discovery.

Accelerate Drug Discovery with Crown Bioscience's Comprehensive DMPK / ADME Services

Cell Line-Derived Xenograft Models, Established multiple in vivo assay systems to evaluate novel anticancer compounds, with each assay specifically designed to understand a drug's mechanism of action, or an individual agent property.

Accelerate oncology drug development with Crown Bioscience’s PDX Mouse Clinical Trials. Leverage the world’s largest clinically relevant PDX collection to model patient tumor heterogeneity, predict clinical outcomes, discover biomarkers, and optimize drug strategies. Improve clinical translation and reduce attrition with highly predictive, patient-relevant insights.

CrownSyn™: Quantify and visualize drug synergy, antagonism, or additivity in vitro and in vivo with Crown Bioscience’s robust bioinformatics platform—empowering oncology researchers to optimize combination therapies with confidence.

Delve into biomarker discovery and drug development with Crown Bioscience’s next-generation proteomics services—leveraging 4D-DIA technology for deep, reproducible protein profiling and post-translational modification analysis.

Unlock immune insights with Crown Bioscience’s high-throughput flow cytometry—precisely characterize immune cell populations across tissues to elucidate drug mechanisms, assess pharmacodynamics, and optimize immunotherapies.

Accelerate the development of your immuno-oncology drugs with Crown Bioscience’s large panel of immunocompetent syngeneic models.

Crown Bioscience’s preclinical biomarker services help identify, validate, and analyze biomarkers across diverse in vitro and in vivo cancer models. Using multi-omics platforms and expert bioinformatics, these services support drug mechanism studies, patient stratification, and companion diagnostic development to guide oncology drug discovery.

PDX Models Empower your research with models that reflect today’s patients and treatments.

Unlock deeper insights into tissue organization and cellular interactions with Crown Bioscience’s spatial biology and digital pathology services, featuring advanced imaging, automated analysis, and high-throughput biomarker screening for applications in cancer research, immunology, and more.

OrganoidXplore™, Organoid Panel Screening Service

Explore your translational research with Crown Bioscience’s comprehensive genomics services—offering PCR/qPCR, next-generation sequencing, and advanced bioinformatics to deliver high-quality, reproducible data for biomarker discovery and drug development.

Automated filtration and filling system designed to accurately and aseptically aliquot bulk product into multiple biocontainer bags or bottles.

eXTReme™ Seal features an extra-strong, thick adhesive to minimize evaporation yet removes easily without leaving residue on the plate.

eXTReme™ Seal features an extra-strong, thick adhesive to minimize evaporation yet removes easily without leaving residue on the plate.

Dextran sulfate sodium salt, or DSS, is a synthetic sulfated branched polysaccharide derivative of dextran that has multiple uses in biomedical and clinical research. One important property of DSS is to triggers colitis in mice and rats when administered in drinking water.  

PhyTip® Gel Filtration columns are unique tools for high throughput micro volume desalting or buffer exchange applications. They represent the only high throughput, automatable, chromatography desalting solution. Unlike standard dialysis, up to 96 samples can be processed at a time in as little time as ~ 30 minutes and in most cases re-concentration is not required at the end. The gel filtration columns are similar to the P…

PhyTip® Columns offer automated, flexible and scalable solution for biomolecule separation.   In addition to columns for affinity purification, nucleic acid purification and gel filtration, PhyNexus have developed PhyTip columns for ion exchange. In traditional ion exchange chromatography, samples, wash buffers and gradient elution buffers pass through packed columns in one direction. The PhyTip column is able to s…

Previously known as Speed-Vap® IV Automated Solvent Evaporation System

Previously known as SolventTrapSVOC Solvent Recovery System