Products & ReviewLife Sciences
PROTAC Targets
Recombinant proteins specifically relevant as E3 ligases or target proteins for Proteolysis Targeting Chimeras (PROTACs), enabling the development of this novel targeted protein degradation technology.
PROTAC Targets
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PROTACs are heterobifunctional molecules that recruit an E3 ubiquitin ligase to a specific target protein, leading to its ubiquitination and degradation by the proteasome. This product category provides the high-quality protein components needed to design, screen, and validate these groundbreaking therapeutic molecules.
Key Features & Benefits:
- Includes Key E3 Ligases (e.g., VHL, CRBN) and Disease-Relevant Targets
- High Purity and Functional Activity for In Vitro Assays
- Essential for Ternary Complex Formation Studies
- Supports High-Throughput Screening Campaigns
Relevant Applications:
- In Vitro PROTAC Screening and Optimization
- Binding Affinity and Kinetics Studies (e.g., SPR)
- Structural Biology for PROTAC Design
- Mechanistic Studies of Targeted Protein Degradation
